Effect of Sustained-release Diamox on the Intra-ocular Pressure in Man.

Dimox and the other carbonic anhydrase inhibitors now form a standard adjunct to the treatment of glaucoma throughout the world, and the literature dealing with these substances is very extensive. In spite of the numerous drugs available, search is continuing for the least toxic and also for one requiring less frequent administration. The present study was carried out to evaluate the action of sustainedrelease Diamox Sequel (Lederle ), produced in a 500-mg. capsule containing 125 mg. ordinary acetazolamide and 375 mg. sustained-release acetazolamide, and to compare it with a single dose of ordinary acetazolamide which starts to reduce intra-ocular pressure after 30 to 90 minutes and reaches its maximum in 1 to 5 hours, the duration of action being somewhere between 8 and 12 hours (Leydhecker, 1960).